HCID 17221248, compound → HCID 67010465, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(pyrimidin-2-yl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 41, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)acetamido)propanamide (17.1 mg, 36.6%). 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 8.36 (d, 2H), 8.06 (d, 1H), 7.60 (d, 2H), 7.23 (m, 7H), 7.02 (m, 4H), 6.63 (t, 1H), 4.71 (m, 1H), 4.53 (s, 2H), 3.73 (m, 7H), 3.06 (s, 2H), 2.54 (m, 5H). MS (EI) for C32H33FN6O4: 585.6 (MH+).

Provenance & Evidence