(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 45376498, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-acetylpiperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 236, (S)-2-(2-(4-acetylpiperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (14.4 mg, 32.8%). 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 8.01 (d, 1H), 7.60 (d, 2H), 7.30 (s, 5H), 7.20 (t, 2H), 7.02 (m, 4H), 4.70 (m, 1H), 4.52 (s, 2H), 3.74 (m, 2H), 3.41 (m, 5H), 3.03 (s, 2H), 2.40 (m, 3H), 1.98 (s, 3H). MS (EI) for C30H33FN4O5: 549.7 (MH+).

Provenance & Evidence