(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67010217, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-ethylpiperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 114, (S)-3-(benzyloxy)-2-(2-(4-ethylpiperazin-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (20.6 mg, 48.2%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 7.93 (d, 1H), 7.60 (d, 2H), 7.31-7.25 (m, 5H), 7.21 (t, 2H), 7.04-6.99 (m, 4H), 4.69 (m, 1H), 4.51 (s, 2H), 3.76 (m, 1H), 3.71 (m, 1H), 2.97 (s, 2H), 2.46 (m, 3H), 2.38 (m, 3H), 2.33-2.28 (m, 4H), 0.98 (t, 3H). MS (EI) for C30H35FN4O4. found 535.6 (MH+).

Provenance & Evidence