(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67010600, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2-(((S)-1-methylpyrrolidin-2-yl)methyl)piperidin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 113, (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-(((S)-1-methylpyrrolidin-2-yl)methyl)piperidin-1-yl)acetamido)propanamide (20.9 mg, 43.3%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.27 (d, 1H), 8.51 (s, 1H), 7.67-7.64 (m, 2H), 7.31 (m, 5H), 7.21 (t, 2H), 7.03-6.98 (m, 4H), 4.72 (m, 1H), 4.52 (d, 2H), 4.16 (m, 1H), 4.04 (m, 1H), 3.77-3.73 (m, 4H), 3.38 (s, 2H), 2.99 (s, 2H), 2.79 (m, 1H), 2.43 (m, 2H), 2.32 (m, 2H), 2.18 (m, 1H), 1.99 (m, 2H), 1.75 (m, 1H), 1.51 (m, 4H), 1.37 (m, 2H). MS (EI) for C35H43FN4O4. found 603.7 (MH+).

Provenance & Evidence