(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 45377856, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 112, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetamido)propanamide (16.9 mg, 32.4%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.23 (s, 1H), 8.54 (d, 1H), 8.06 (t, 2H), 7.61 (d, 2H), 7.30 (m, 4H), 7.27-7.19 (m, 4H), 7.04-6.98 (m, 4H), 4.72 (m, 1H), 4.53 (s, 2H), 3.76 (m, 2H), 3.20 (t, 4H), 3.08 (s, 2H), 2.63 (m, 4H). MS (EI) for C34H33F4N5O4. found 652.6 (MH+).

Provenance & Evidence