HCID 46735914, compound → HCID 67010388, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-isopropylpiperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound III, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-isopropylpiperazin-1-yl)acetamido)propanamide (19.8 mg, 45.1%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.22 (s, 1H), 7.92 (d, 1H), 7.59 (d, 2H), 7.30 (m, 5H), 7.21 (t, 2H), 7.04-6.98 (m, 4H), 4.70 (m, 1H), 4.52 (s, 2H), 3.77 (m, 1H), 3.71 (m, 1H), 2.96 (d, 2H), 2.61 (m, 1H), 2.50 (t, 8H), 0.95 (d, 6H). MS (EI) for C31H37FN4O4. found 549.7 (MH+).

Provenance & Evidence