(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009801, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 237, (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)acetamido)propanamide (19.3 mg, 39.9%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.24 (s, 1H), 8.03 (d, 1H), 7.61 (d, 2H), 7.30 (m, 5H), 7.21 (t, 2H), 7.04-6.99 (m, 4H), 4.70 (m, 1H), 4.65 (t, 1H), 4.53 (s, 2H), 3.78-3.72 (m, 4H), 3.35 (m, 6H), 3.04 (s, 2H), 2.44 (m, 2H), 1.97 (dd, 2H), 1.80 (m, 2H). MS (EI) for C33H37FN4O6. found 605.7 (MH+).

Provenance & Evidence