(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67010398, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(methoxycarbonyl)piperidin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 238, (S)-methyl 1-(2-(3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)piperidine-4-carboxylate (22.7 mg, 50.3%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 7.95 (d, 1H), 7.60 (d, 2H), 7.29 (m, 5H), 7.21 (t, 2H), 7.04-6.98 (m, 4H), 4.69 (m, 1H), 4.52 (s, 2H), 3.77 (m, 1H), 3.70 (m, 1H), 3.61 (s, 3H), 2.96 (s, 2H), 2.80 (m, 2H), 2.32 (m, 1H), 2.12 (t, 2H), 1.79 (m, 2H), 1.60 (m, 2H). MS (EI) for C31H34FN3O6. found 564.6 (MH+).

Provenance & Evidence