(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 67009795, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 110, (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)acetamido)propanamide (23.1 mg, 48.9%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.21 (s, 1H), 7.92 (d, 1H), 7.60 (d, 2H), 7.29 (m, 5H), 7.21 (t, 2H), 7.03-6.97 (m, 4H), 4.69 (m, 1H), 4.52 (s, 2H), 3.89 (m, 1H), 3.79-3.68 (m, 3H), 3.59 (m, 1H), 2.96 (s, 2H), 2.45 (m, 5H), 2.34 (m, 5H), 1.89 (m, 1H), 1.76 (m, 2H), 1.44 (m, 1H). MS (EI) for C33H39FN4O5. found 591.7 (MH+).

Provenance & Evidence