HCID 67009785, compound → HCID 178520355, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 1H-imidazol-4-ylacetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(3-phenoxyphenyl)propanamide, gave Compound 243, (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(3-phenoxyphenyl)propanamide (100 mg, 21%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 11.87 (br s, 1H), 10.28 (s, 1H), 8.42-8.41 (d, 1H), 7.54-7.43 (m, 10H), 7.18-7.14 (t, 1H), 7.05-7.03 (d, 2H), 6.95 (s, 1H), 6.75-6.67 (d, 1H), 4.69-4.62 (m, 1H), 4.49 (s, 1H), 3.69-3.60 (m, 2H), 3.51-3.40 (m, 2H). MS (EI) for C27H26N4O4. found 471.0 (MH+).

Provenance & Evidence