(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 178425867, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(3-methyl-1H-pyrazol-5-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 166, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)acetamido)propanamide (48 mg, 49%). 1H-NMR (400 MHz, DMSO-D6): σ 12.07 (s, 1H), 10.18 (s, 1H), 8.38 (s, 1H), 7.65-7.58 (m, 2H), 7.35-7.17 (m, 6H), 7.06-6.95 (m, 4H), 5.86 (s, 1H), 4.73-4.64 (m, 1H), 4.52 (s, 2H), 3.66 (d, 2H), 3.46 (s, 2H), 2.15 (s, 3H). MS (EI) for C28H27FN4O4. found 503.0 (MH+).

Provenance & Evidence