(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 178460291, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-imidazol-4-yl)propanoic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 167, (2S)-2-(2-(1H-imidazol-4-yl)propanamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (49 mg, 21%). 1H-NMR (400 MHz, CDCl3): δ 9.80 (s, 1H), 9.46 (s, 1H), 9.38 (br s, 1H), 7.80-7.15 (m, 9H), 7.00-6.79 (m, 6H), 4.82-4.71 (m, 1H), 4.54-4.38 (m, 2H), 4.01-3.59 (m, 3H), 1.45-1.34 (m, 3H). MS (EI) for C28H27FN4O4 found 503 (MH+).

Provenance & Evidence