HCID 16192989, compound → HCID 67010692, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-methyl-2-(1H-1,2,4-triazol-1-yl)propanoic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 255, (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-methyl-2-(1H-1,2,4-triazol-1-yl)propanamido)propanamide (93.3 mg, 36%). 1H-NMR (400 MHz, CDCl3): δ 8.45 (s, 1H), 8.30 (s, 1H), 8.07 (s, 1H), 7.42 (d, 2H), 7.39-7.24 (m, 7H), 7.11 (d, 1H), 7.05-6.91 (m, 5H), 4.65-4.59 (m, 2H), 4.50 (d, 1H), 4.00 (dd, 1H), 3.58-3.52 (m, 1H), 1.92 (s, 3H), 1.90 (s, 3H). MS (EI) for C28H28FN5O4 found 518 (MH+).

Provenance & Evidence