(S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide → HCID 45376626, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (S)-2-amino-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 256, (S)-3-(benzyloxy)-2-(2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide (219 mg, 27%). 1H-NMR (400 MHz, CDCl3): σ 8.38 (s, 1H), 7.40-7.16 (m, 7H), 7.05-6.92 (m, 5H), 4.74 (s, 2H), 4.70-4.64 (m, 3H), 4.55 (d, 1H), 4.02-3.97 (m, 1H), 3.62-3.56 (m, 1H), 2.44 (s, 3H), 2.33 (s, 3H). MS (EI) for C28H28FN5O4. found 518.0 (MH+).

Provenance & Evidence