2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride → HCID 45376098, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)-4-(2,4-dichlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 180, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2,4-dichlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (48 mg, 35%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.03 (s, 1H), 8.43 (s, 1H), 7.96 (s, 1H), 7.68-7.35 (m, 5H), 7.19 (t, 2H), 7.07-6.88 (m, 4H), 5.24 (q, 2H), 4.57-4.48 (m, 1H), 3.91-3.78 (m, 1H), 2.97-2.70 (m, 3H), 2.11-1.88 (m, 3H). MS (EI) for C28H24FN5O3. found 569.8 (MH+).

Provenance & Evidence