反应详情

Proceeding as in Example 1, but substituting 2-(2H-1,2,3-triazol-2-yl)acetic acid hydrochloride and (2S,4S)—N-(4-(4-fluorophenoxy)phenyl)-4-phenylpyrrolidine-2-carboxamide, gave Compound 77, (2S,4S)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-phenylpyrrolidine-2-carboxamide (170 mg, 62%). 1H-NMR (400 MHz, CDCl3): σ 9.21 (s, 1H), 7.74 (s, 2H), 7.48 (d, 2H), 7.40-7.36 (m, 2H), 7.32-7.29 (m, 3H), 7.04-6.99 (m, 2H), 6.96-6.92 (m, 4H), 5.35 (s, 2H), 5.00 (d, 1H), 3.93 (t, 1H), 3.89-3.80 (m, 1H), 3.54 (t, 1H), 2.91 (dd, 1H), 2.18-2.09 (m, 1H). MS (EI) for C27H24FN5O3. found 486.1 (MH+).