HCID 12196794, compound → HCID 67010197, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 4-oxopentanoic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 123, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(4-oxopentanoyl)pyrrolidine-2-carboxamide (2.2 mg, 7.5%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.88 (s, 1H), 7.55-7.60 (m, 2H), 7.29-7.32 (m, 2H), 7.17-7.23 (m, 5H), 6.95-7.02 (m, 4H), 4.45 (m, 1H), 3.65 (m, 1H), 3.25 (m, 1H), 2.60-2.69 (m, 3H), 2.57-2.59 (m, 2H), 2.44-2.53 (m, 2H), 2.45 (s, 3H), 1.92 (m, 2H). MS (EI) for C29H29FN2O4. found 489.5 (MH+).

Provenance & Evidence