(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010440, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-methoxyacetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 122, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-methoxyacetyl)pyrrolidine-2-carboxamide (12 mg, 43.2%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.97 (s, 1H), 7.56-7.59 (m, 2H), 7.28-7.32 (m, 2H), 7.17-7.23 (m, 5H), 6.94-7.02 (m, 4H), 4.50 (m, 1H), 4.04 (m, 1H), 3.60 (m, 1H), 3.28 (s. 3H), 3.18 (m, 2H), 2.65 (m, 3H), 1.90 (m, 2H). MS (EI) for C27H27FN2O4. found 463.5 (MH+).

Provenance & Evidence