(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010391, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2,6-dichlorophenyl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 119, (2S,4R)-4-benzyl-1-(2-(2,6-dichlorophenyl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (12.1 mg, 34.9%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): a 9.92 (s, 1H), 7.54-7.60 (m, 2H), 7.44 (d, 2H), 7.25-7.34 (m, 5H), 7.15-7.24 (m, 3H), 6.93-7.03 (m, 4H), 4.48-4.51 (m, 1H), 3.95 (m, 2H), 3.50-3.59 (m, 1H), 3.15 (m, 1H), 2.63-2.73 (m, 3H), 1.89-1.93 (m, 2H). MS (EI) for C32H27C12FN2O3. found 578.4 (MH+).

Provenance & Evidence