(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010173, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 3-hydroxybutanoic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 118, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3-hydroxybutanoyl)pyrrolidine-2-carboxamide (8.5 mg, 29.7%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.93 (s, 1H), 7.55-7.60 (m, 2H), 7.28-7.35 (m, 2H), 7.17-7.24 (m, 5H), 6.94-7.02 (m, 4H), 4.67 (m, 1H), 4.47-4.50 (m, 1H), 3.90 (m, 1H), 3.68-3.70 (m, 1H), 3.25-3.30 (m, 1H), 2.63-2.73 (m, 3H), 2.35-2.47 (m, 1H), 2.70-2.30 (m, 1H), 1.86-1.96 (m, 2H), 1.01-1.13 (m, 3H). MS (EI) for C28H29FN2O4. found 477.5 (MH+).

Provenance & Evidence