(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010222, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(thien-2-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 117, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(thien-2-yl)acetyl)pyrrolidine-2-carboxamide (12.3 mg, 39.8%); Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.34 (s, 1H), 7.55-7.60 (m, 2H), 7.37-7.39 (m, 2H), 7.28-7.32 (m, 2H), 7.17-7.23 (m, 5H), 6.94-7.03 (m, 6H), 4.48-4.51 (m, 1H), 3.90 (d, 2H), 3.75-3.80 (m 1H), 3.56 (m, 1H), 2.63-2.73 (m, 3H), 1.88-1.97 (m, 2H). MS (EI) for C30H27FN2O3S. found 515.6 (MH+).

Provenance & Evidence