(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 86659481, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 99, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(4-oxo-2-thioxothiazolidin-3-yl)acetyl)pyrrolidine-2-carboxamide (13.5 mg, 39.9%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.92 (s, 1H), 7.51 (d, 2H), 7.30-7.16 (m, 9H), 6.93 (m, 2H), 4.76 (m, 1H), 4.60 (m, 1H), 4.43 (m, 1H), 4.35 (m, 2H), 2.87 (s, 2H), 2.68 (m, 3H), 1.95 (m, 2H). MS (EI) for C29H26FN3O4S2. found 564.7 (MH+).

Provenance & Evidence