(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009450, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-indol-3-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 98, (2S,4R)-1-(2-(1H-indol-3-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (12.9 mg, 39.3%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 10.91 (s, 1H), 9.99 (s, 1H), 7.56 (m, 3H), 7.35-7.07 (m, 10H), 7.01-6.94 (m, 5H), 4.50 (m, 1H), 3.75 (m, 2H), 3.69 (s, 2H), 2.61 (m, 3H), 1.90 (m, 2H). MS (EI) for C34H30FN3O3. found 548.6 (MH+).

Provenance & Evidence