(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010437, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 97, (2S,4R)-4-benzyl-1-(2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (13.9 mg, 40.1%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.94 (s, 1H), 7.86 (m, 4H), 7.51 (d, 2H), 7.31-7.13 (m, 9H), 6.91 (m, 2H), 4.52 (d, 1H), 4.47-4.40 (m, 2H), 3.84 (m, 1H), 3.39 (m, 1H), 2.67 (m, 3H), 1.94 (m, 2H). MS (EI) for C34H28FN3O5. found 578.6 (MH+).

Provenance & Evidence