(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 45377718, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(pyridin-4-ylthio)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 96, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(pyridin-4-ylthio)acetyl)pyrrolidine-2-carboxamide (4 mg, 12.3%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.97 (s, 1H), 8.34 (d, 2H), 7.55 (m, 2H), 7.33-7.28 (m, 5H), 7.25-7.18 (m, 6H), 6.95 (m, 2H), 4.49 (m, 1H), 4.14 (m, 2H), 3.86 (m, 1H), 3.56 (m, 1H), 2.69 (m, 3H), 1.95 (m, 2H). MS (EI) for C31H28FN3O3S. found 542.6 (MH+).

Provenance & Evidence