(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009431, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(pyrimidin-2-ylthio)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 94, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(pyrimidin-2-ylthio)acetyl)pyrrolidine-2-carboxamide (10.9 mg, 33.5%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): a 9.92 (s, 1H), 8.59 (d, 2H), 7.53 (m, 2H), 7.27 (m, 2H), 7.23-7.15 (m, 8H), 6.93 (m, 2H), 4.47 (m, 1H), 4.09 (m, 2H), 3.78 (m, 1H), 3.39 (m, 1H), 2.68 (m, 3H), 1.93 (m, 2H). MS (EI) for C30H27FN4O3S. found 543.6 (MH+).

Provenance & Evidence