(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010455, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting (S)-1-acetylpyrrolidine-2-carboxylic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 93, (2S,4R)-1-((S)-1-acetylpyrrolidine-2-carbonyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (11.5 mg, 36.2%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.96 (s, 1H), 7.54 (m, 2H), 7.29-7.24 (m, 4H), 7.20-7.14 (m, 5H), 6.93 (m, 2H), 4.46 (m, 2H), 3.47-3.37 (m, 4H), 2.66 (m, 2H), 1.95-1.83 (m, 8H), 1.76-1.69 (m, 2H). MS (EI) for C31H32FN3O4. found 530.6 (MH+).

Provenance & Evidence