(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 45377717, compound

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Reaction Steps

Proceeding as in Example 1, but substituting tetrahydrofuran-2-carboxylic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 92, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(tetrahydrofuran-2-carbonyl)pyrrolidine-2-carboxamide (9.8 mg, 33.4%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): a 9.97 (s, 1H), 7.54 (m, 2H), 7.27 (m, 2H), 7.21-7.15 (m, 7H), 6.93 (m, 2H), 4.55-4.43 (m, 2H), 3.73 (m, 2H), 2.64 (m, 3H), 2.03-1.90 (m, 4H), 1.86-1.76 (m, 4H). MS (EI) for C29H29FN2O4. found 489.5 (MH+).

Provenance & Evidence