(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009861, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 3-methoxypropanoic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 90, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3-methoxypropanoyl)pyrrolidine-2-carboxamide (6.9 mg, 24.1%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): 9.90 (s, 1H), 7.54 (m, 2H), 7.30-7.25 (m, 3H), 7.21-7.16 (m, 6H), 6.92 (m, 2H), 4.44 (m, 1H), 3.66 (m, 1H), 3.51 (m, 3H), 3.19 (s, 3H), 2.63 (m, 4H), 2.09 (m, 1H), 1.88 (m, 2H). MS (EI) for C28H29FN2O4. found 477.5 (MH+).

Provenance & Evidence