(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009498, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 4-(dimethylamino)-4-oxobutanoic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 89, (2S,4R)-4-benzyl-1-(4-(dimethylamino)-4-oxobutanoyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (6.2 mg, 20%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.68 (s, 1H), 7.57 (m, 2H), 7.27 (m, 2H), 7.23-7.15 (m, 7H), 6.93 (m, 2H), 4.43 (m, 1H), 3.68 (m, 1H), 3.27 (m, 1H), 2.94 (s, 3H), 2.78 (s, 3H), 2.67-2.58 (m, 4H), 2.44 (m, 3H), 1.91 (m, 2H). MS (EI) for C30H32FN3O4. found 518.6 (MH+).

Provenance & Evidence