(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009396, compound

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Reaction Steps

Proceeding as in Example 1, but substituting 2-(methylsulfonyl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 87, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(methylsulfonyl)acetyl)pyrrolidine-2-carboxamide (7.6 mg, 24.8%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.96 (s, 1H), 7.55 (m, 2H), 7.27 (m, 2H), 7.23-7.16 (m, 7H), 6.94 (m, 2H), 4.50 (m, 1H), 4.38 (d, 2H), 3.82 (m, 1H), 3.35 (m, 1H), 3.08 (s, 3H), 2.63 (m, 3H), 1.92 (m, 2H). MS (EI) for C27H27FN2O5S. found 511.6 (MH+).

Provenance & Evidence