(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 45377296, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting (R)-2-hydroxy-2-phenylacetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 40, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-((R)-2-hydroxy-2-phenylacetyl)pyrrolidine-2-carboxamide (8.4 mg, 26.7%). 1H-NMR (400 MHz, DMSO-D6): σ 10.03 (s, 1H), 7.56 (d, 2H), 7.27 (m, 11H), 6.97 (m, 5H), 5.20 (s, 1H), 4.44 (t, 1H), 2.86 (t, 2H), 2.71 (s, 1H), 2.45 (d, 2H), 1.80 (m, 2H). MS (EI) for C32H29FN2O4: 525.4 (MH+).

Provenance & Evidence