(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010817, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting (S)-5-oxotetrahydrofuran-2-carboxylic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 39, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-((S)-5-oxotetrahydrofuran-2-carbonyl)pyrrolidine-2-carboxamide (8.8 mg, 29.2%). 1H-NMR (400 MHz, DMSO-D6): σ 10.04 (s, 1H), 7.53 (m, 2H), 7.27 (m, 2H), 7.18 (m, 5H), 6.94 (m, 4H), 5.28 (m, 1H), 4.52 (dd, 1H), 3.65 (m, 1H), 2.39 (m, 3H), 2.46 (m, 3H), 2.15 (m, 2H), 2.89 (m, 2H). MS (EI) for C29H27FN2O5: 503.5 (MH+).

Provenance & Evidence