4-N,N-dimethylaminophenylacetic acid → HCID 67009557, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(dimethylamino)phenyl)acetic acid and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 35, (2S,4R)-4-benzyl-1-(2-(4-(dimethylamino)phenyl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (2.5 mg, 7.6%). 1H-NMR (400 MHz, DMSO-D6): σ 9.95 (s, 1H), 7.56 (m, 2H), 7.23 (t, 2H), 7.12 (m, 5H), 6.98 (m, 6H), 6.64 (m, 2H), 4.46 (m, 1H), 3.49 (s, 2H), 3.24 (m, 1H), 2.84 (s, 6H), 2.60 (m, 3H), 1.87 (m, 2H). MS (EI) for C34H34FN3O3: 552.6 (MH+).

Provenance & Evidence