(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67009338, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)butanoic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 33, (2S,4R)-4-benzyl-1-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)butanoyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (8.4 mg, 23.5%). 1H-NMR (400 MHz, DMSO-D6): σ 9.93 (s, 1H), 7.54 (d, 2H), 7.26 (t, 2H), 7.18 (m, 5H), 6.98 (m, 4H), 6.71 (d, 1H), 6.45 (m, 2H), 4.45 (m, 1H), 4.17 (m, 4H), 3.57 (m, 1H), 3.14 (m, 1H), 2.64 (m, 3H), 2.64 (t, 2H), 2.19 (m, 2H), 1.87 (m, 2H), 1.70 (m, 2H). MS (EI) for C36H35FN2O5: 595.7 (MH+).

Provenance & Evidence