1158584-44-1 → HCID 67010270, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-thiomorpholinoacetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 83, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-thiomorpholinoacetyl)pyrrolidine-2-carboxamide (13.9 mg, 37.2%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.95 (s, 1H), 7.54 (d, 2H), 7.27 (m, 2H), 7.21-7.16 (m, 7H), 6.93 (m, 2H), 4.44 (m, 1H), 3.71 (m, 1H), 3.28 (m, 1H), 3.13 (m, 2H), 2.87 (m, 4H), 2.63 (m, 3H), 2.55 (m, 4H), 1.85 (m, 2H). MS (EI) for C30H32FN3O3S. found 534.7 (MH+).

Provenance & Evidence