2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, hydrochloride → HCID 67010812, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(3,4-dihydroisoquinolin-2(1H)-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 82, (2S,4R)-4-benzyl-1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (13.7 mg, 34.7%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.98 (s, 1H), 7.56 (d, 2H), 7.23-7.15 (m, 10H), 7.09 (m, 3H), 6.94 (m, 2H), 4.49 (m, 1H), 3.74 (m, 1H), 3.63 (d, 2H), 3.36 (m, 1H), 3.29 (s, 2H), 2.78-2.73 (m, 4H), 2.61 (m, 3H), 1.91 (m, 2H). MS (EI) for C35H34FN3O3. found 564.7 (MH+).

Provenance & Evidence