(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 45377719, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(4-(2-methoxyethyl)piperazin-1-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 100, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(4-(2-methoxyethyl)piperazin-1-yl)acetyl)pyrrolidine-2-carboxamide (10.6 mg, 26.3%). Major isomer: 1H-NMR (400 MHz, DMSO-D6): σ 9.96 (s, 1H), 7.61 (d, 1H), 7.54 (d, 1H), 7.28 (m, 2H), 7.22-7.13 (m, 5H), 6.99-6.92 (m, 4H), 4.45 (m, 1H), 3.73 (m, 1H), 3.39 (m, 2H), 3.23 (t, 1H), 3.20 (s, 2H), 3.13 (s, 2H), 3.07 (m, 1H), 2.63 (m, 2H), 2.48 (m, 8H), 2.43 (t, 2H), 2.09 (t, 1H), 1.91 (m, 2H). MS (EI) for C33H39FN4O4. found 575.7 (MH+).

Provenance & Evidence