(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide → HCID 67010497, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-((1-methyl-1H-indol-2-yl)methylamino)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 30, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-((1-methyl-1H-indol-2-yl)methylamino)acetyl)pyrrolidine-2-carboxamide (12.6 mg, 30.4%). 1H-NMR (400 MHz, DMSO-D6): σ 9.95 (s, 1H), 7.93 (m, 2H), 7.26 (m, 4H), 7.17 (m, 8H), 6.96 (m, 3H), 4.15 (m, 1H), 3.64 (m, 1H), 3.49 (m, 2H), 3.14 (m, 2H), 2.87 (s, 3H), 2.64 (m, 2H), 2.20 (m, 1H), 1.89 (m, 2H). MS (EI) for C35H34FN5O3: 592.7 (MH+).

Provenance & Evidence