反应详情

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 9, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (35.4 mg, 36%). Major isomer 1H-NMR (400 MHz, CDCl3): δ 9.08 (s, 1H), 8.27 (s, 1H), 7.98 (s, 1H), 7.37-7.33 (m, 2H), 7.23-7.19 (m, 1H), 7.16-7.12 (m, 1H), 7.02-6.82 (m, 7H), 5.07 (d, 1H), 5.00 (d, 1H), 4.73 (d, 1H), 3.75-3.69 (m, 1H), 3.31 (t, 1H), 3.08-2.98 (m, 1H), 2.88 (d, 2H), 2.46 (dd, 1H), 1.82-1.73 (m, 1H). MS (EI) for C28H24ClF2N5O3 found 552 (MH+).