2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride → HCID 45377579, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(thien-3-ylmethyl)pyrrolidine-2-carboxamide, gave Compound 72, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(thiophen-3-ylmethyl)pyrrolidine-2-carboxamide (172 mg, 35%). 1H-NMR (400 MHz, CDCl3): δ 9.03 (s, 1H), 8.24 (s, 1H), 7.99 (s, 1H), 7.42 (d, 2H), 7.32-7.30 (m, 1H), 7.03-6.90 (m, 8H), 5.05 (d, 1H), 4.97 (d, 1H), 4.81 (d, 1H), 3.87 (t, 1H), 3.24 (t, 1H), 3.05-2.97 (m, 1H), 2.96-2.89 (m, 1H), 2.77-2.64 (m, 2H), 1.73-1.65 (m, 1H). MS (EI) for C26H24FN5O3S found 505.9 (MH+).

Provenance & Evidence