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HRID1630240

反应详情

EQUATION

反应方程式

HRID 1630240 的结构方程式

REACTANTS

反应物

2
结构：Cl.O=C(O)Cn1cncn1
HCID44887050

1H-1,2,4-Triazole-1-acetic acid, monohydrochloride

C4H6ClN3O2

结构：O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2cccc(Cl)c2)CN1
HCID67009149

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2cccc(Cl)c2)CN1C(=O)Cn1cncn1
HCID46191262

未命名化合物

收率 60%

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)-4-(3-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 61, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(3-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (65 mg, 60%). 1H-NMR (400 MHz, CDCl3): δ 9.00 (s, 1H), 8.20 (s, 1H), 8.00 (s, 1H), 7.40-7.20 (m, 6H), 6.90-6.80 (m, 6H), 5.00 (dd, 2H), 4.90 (d, 1H), 3.80 (m, 1H), 3.20 (m, 1H), 3.00-2.80 (m, 5H). MS (EI) for C28H25ClFN5O3 found 534 (MH+).