(1H-1,2,3-Triazol-1-yl)acetic acid--hydrogen chloride (1/1) → HCID 67009930, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(1H-1,2,3-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide, gave Compound 3, (2S,4R)-5-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide. 1H-NMR (400 MHz, CDCl3): σ 8.96 (br s, 1H), 7.77 (s, 1H), 7.74 (s, 1H), 7.42 (m, 2H), 7.13 (d, 2H), 7.08 (d, 2H), 7.03-6.98 (m, 2H), 6.94-6.87 (m, 4H), 5.27 (d, 1H), 5.13 (d, 1H), 4.76 (d, 1H), 3.66 (m, 1H), 3.26 (t, 1H), 3.02-2.85 (m, 2H), 2.66-2.57 (m, 2H), 2.33 (s, 3H), 1.76-1.68 (m, 1H); MS (EI) for C29H28FN5O3. found 514.1 (MH+).

Provenance & Evidence