反应详情

Proceeding as in Example 1, but substituting 2-(2H-1,2,3-triazol-2-yl)acetic acid hydrochloride and (2S,4R)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 7, (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (106.7 mg, 34%). Major isomer: 1H-NMR (400 MHz, CDCl3): δ 9.15 (s, 1H), 7.72 (s, 2H), 7.43-7.38 (m, 2H), 7.09-6.81 (m, 9H), 5.29 (d, 2H), 4.84 (d, 1H), 3.59-3.53 (m, 1H), 3.19 (t, 1H), 2.96-2.87 (m, 1H), 2.82 (dd, 1H), 2.72-2.59 (m, 2H), 2.32 (s, 3H). MS (EI) for C29H28F2N5O3 found 532 (MH+).