反应详情

Proceeding as in Example 1, but substituting 2-(1H-1,2,3-triazol-1-yl)acetic acid hydrochloride and (2S,4R)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 6, (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (142 mg, 46%). Major isomer: 1H-NMR (400 MHz, CDCl3): δ 8.96 (s, 1H), 7.76 (d, 2H), 7.40 (d, 2H), 7.11-6.83 (m, 9H), 5.31 (d, 1H), 5.15 (d, 1H), 4.77 (d, 1H), 3.71 (t, 1H), 3.30 (t, 1H), 3.02-2.91 (m, 1H), 2.82 (dd, 1H), 2.71 (dd, 1H), 2.57 (dd, 1H), 2.33 (s, 3H), 1.78-1.68 (m, 1H). MS (EI) for C29H28F2N5O3 found 532 (MH+).