(1H-1,2,3-Triazol-1-yl)acetic acid--hydrogen chloride (1/1) → HCID 45377439, Verbindung

Beteiligte Stoffe

Reaktionsschritte

Proceeding as in Example 1, but substituting 2-(1H-1,2,3-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide, gave Compound 68, (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide (176 mg, 91%). 1H-NMR (400 MHz, CDCl3): σ 8.95 (s, 1H), 7.78 (s, 1H), 7.75 (s, 1H), 7.43 (d, 2H), 7.00 (t, 2H), 6.93-6.89 (m, 4H), 6.79-6.88 (m, 4H), 5.27 (d, 1H), 5.15 (d, 1H), 4.78 (d, 1H), 4.80 (d, 1H), 3.81 (s, 3H), 3.67 (dd, 1H), 3.27 (t, 1H), 3.07-2.88 (m, 2H), 2.66-2.61 (m, 2H), 1.77-1.69 (m, 1H). MS (EI) for C29H28FN5O4. found 530.2 (MH+).

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