反应详情

Proceeding as in Example 1, but substituting 2-(2H-1,2,3-triazol-2-yl)acetic acid hydrochloride and (2S,4S)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 66, (2S,4S)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (58.3 mg, 58%). 1H-NMR (400 MHz, CDCl3): σ 9.14 (s, 1H), 7.72 (s, 2H), 7.42 (d, 2H), 7.00 (t, 2H), 6.95-6.90 (m, 4H), 6.75 (d, 1H), 6.61 (d, 1H), 5.39 (s, 2H), 4.86 (d, 1H), 3.62 (dd, 1H), 3.19 (t, 1H), 3.03-2.85 (m, 2H), 2.83-2.77 (m, 1H), 2.72 (dd, 1H), 1.72-1.64 (m, 1H). MS (EI) for C26H23ClFN5O3S. found 540.1 (MH+).