2-(2H-1,2,3-triazol-2-yl)acetic acid hydrochloride → HCID 46191473, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting 2-(2H-1,2,3-triazol-2-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(2-methylbenzyl)pyrrolidine-2-carboxamide, gave Compound 48, (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2-methylbenzyl)pyrrolidine-2-carboxamide. Major isomer: 1H-NMR (400 MHz, DMSO-D6): δ 9.98 (s, 1H), 7.80 (s, 1H), 7.54 (d, 2H), 7.24-7.08 (m, 6H), 7.04-6.92 (m, 4H), 5.49 (q, 2H), 4.53-4.48 (m, 1H), 3.90-3.83 (m, 1H), 2.80-2.62 (m, 3H), 2.29 (s, 3H), 2.05-1.88 (m, 2H). MS (EI) for C29H28FN5O3. found 514.2 (MH+).

Provenance & Evidence