HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,4-Triazole-1-acetic acid → benzyl (3R,5S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,4-Triazole-1-acetic acid | HCID 1810180 | — |
| Reactant | benzyl (3R,5S)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate | HCID 68201126 | — |
| Product | benzyl (3R,5S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate | HCID 86659490 | 72% |
Reaction Steps
Proceeding as in Example 1, but substituting benzyl (3R,5S)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate and 2-(1H-1,2,4-triazol-1-yl)acetic acid, gave benzyl (3R,5S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate (1.57 g, 2.81 mmol, 72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791102B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-790e645bcd804c2e8f701e65e8c0f419 |
| Source note | uspto-grants-2014_07 |