Acetate-hydrochloric acid → HCID 178475080, compound

Participants

Reaction Steps

Proceeding as in Example 1, but substituting acetic acid hydrochloride and (R)-2-(benzyloxy)-1-(5-(4-fluorophenoxy)-1H-benzo[d]imidazol-2-yl)ethanamine, gave Compound 60, (R)—N-(2-(benzyloxy)-1-(5-(4-fluorophenoxy)-1H-benzo[d]imidazol-2-yl)ethyl)acetamide (22 mg, 32%). 1H-NMR (400 MHz, CDCl3): σ 7.50 (d, 1H), 7.38-7.30 (m, 5H), 7.13 (br s, 1H), 7.03-6.93 (m, 5H), 6.71 (d, 1H), 5.33 (q, 1H), 4.68-4.58 (m, 2H), 4.19 (dd, 1H), 3.86 (dd, 1H), 2.06 (s, 3H). MS (EI) for C24H22FN3O3. found 420.2 (MH+).

Provenance & Evidence